Transdermal menopause hormone therapy is administered through the skin using patches, gels, creams, and sprays. This treatment absorbs estrogen and sometimes progestin (if necessary) directly into the bloodstream. The hormones penetrate the skin barrier and enter the blood vessels, ensuring a steady absorption into the bloodstream. It's available in: Patches Applied on a clean and dry skin of the lower abdomen, upper thighs, and buttocks. Changed according to the prescribed schedule. Gel and Cream Applied daily on arms, legs, shoulders, or abdomen. Requires drying time before covering with clothing to ensure proper absorption. Spray Applied daily through metered-dose spray on the forearm (between the elbow and the wrist) and inner thigh. Requires drying time before covering with clothing to ensure proper absorption. Transdermal Efficacy Transdermal menopause hormone therapy benefits the liver and digestive system because it bypasses first-pass metabolism in the liver and avoids dir...